Radiation interaction with DNA

نویسندگان

  • A. Deppman
  • J. O. Echeimberg
  • A. N. Gouveia
  • J.D.T. Arruda-Neto
  • F. M. Milian
  • N. Added
  • M. E. Camargo
  • F. Guzman
  • V. P. Likhachev
  • O. Rodriguez
چکیده

We developed a model to describe the radiation-DNA interaction in water solution. The model is based on some important aspects of the Bethe Theory for the ionizing process, and on the assumption that the direct interaction between the incident particle and the DNA molecule is negligible in comparison with the indirect effect. This assumption can always be true under controlled conditions. The results show that the number of damages induced by radiation depends on the accumulated dose, on parameters related only to the medium properties, and on the DNA structure, but not on the incident particle. A few applications of the model are discussed, and results are successfully compared with experimental data. New experiments are proposed.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Mechanism of Calf thymus DNA radioprotection by sucrose: A combined effect of scavenging action and altered water

Background: Development of safe radioprotector is a challenging task. In this study radioprotective effect of sucrose has been demonstrated in calf thymus DNA (CtDNA). Sucrose is a free radical scavenger and also acts as osmolyte and therefore can influence the water activity around DNA and effects of radiation on DNA. Hoechst 33258 was used to probe the possible alteration in physicochemical p...

متن کامل

An investigation of neutron direct damages at energies of 0.1-2 MeV on the DNA molecules with atomic structure deduced using Geant4 toolkit

This study proposes a method to estimate RBE of fast neutrons using Monte Carlo simulations. This approach is based on the combination of an atomic resolution DNA geometrical model and Monte Carlo simulations for tracking particles. Atomic positions were extracted from the Protein Data Bank. The GEANT4 code was used for tracking the secondary particles generated by fast neutrons during their in...

متن کامل

Investigation of Solvent Effects on Interaction of Single-Strand DNA with Open-End of Single Walled Carbon Nanotubes Using QM and MM methods

The interaction of biomolecules with carbon nanotubes (CNTs) has generated a great deal ofinterest in the past few years. The interaction between B-form single-strand DNA (ssDNA) andsingle-walled carbon nanotubes (SWCNTs) is a subject of intense current interest; however thereare a relatively small number of papers in the literature dealing with interaction of DNA andSWCNTs. In this work we inv...

متن کامل

Changes in the Radiation Toxicity of Human Lymphoblastic T-cell Line (Jurkat) by a Common Pesticide: Diazinon

Background: Diazinon is one of the most common pesticides in the world playing a similar role to radiation and it could cause DNA breaks and genetic effects.Objective: In this study, radiosensitivity of a lymphoblastic cell line pretreated by Diazinon was investigated. Material and Methods: In this case-control study, the human lymphoblastic T-cell line was divided into 6 groups bas...

متن کامل

Modeling the distribution of deposited energy by alpha particles from Radon 223 decay and its effect on DNA

 The ionizing radiations, through physical and chemical processes, lead to simple and complex single- and double- strand breaks, as well as base lesions to the DNA. In this study, taking into account all the physical and chemical processes involved in the interaction of ionizing radiation with matter, the initial damage induced to DNA was evaluated for 5.7 MeV alpha-rays from Radon 223 isotope....

متن کامل

Combined Effects of 528 Hz Sound and X-ray in Peripheral Blood Lymphocytes

Introduction: Radiotherapy is still one of the main options for cancer treatment but it is in association with damage to normal cells as well as the tumor cells. To reduce the injury in normal cells we have evaluated the effect of 528 hertz sound after X irradiation in peripheral blood lymphocytes. Materials and Methods: in this study, peripheral blood was o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2004